Glycoprotein gp130 has a molecular mass of 130–150 kDa; gp130 has the alternative names IL-6Rβ, CD130, and IL-6 signal transducer. The molecular cloning of human gp130cDNA was reported in 1990 (database accession, M57230).

2001-03-16

Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. 2000-02-08 2018-10-02 2003-09-15 Enrichment of STAT3 regulation and gp130-ligands in activated fibroblasts and macrophages led us to reason that gp130 blockade might rescue the activated program. 2005-11-01 2001-03-16 2015-03-05 2017-01-16 2003-09-23 We have previously reported that gp130 ΔSTAT/ΔSTAT mice, which express a truncated gp130 receptor unable to bind and activate STAT1 and STAT3, display leukocytosis and thrombocytopenia, thus demonstrating the requirement for gp130-dependent STAT1 and/or STAT3 signaling to maintain hematopoietic homeostasis in the adult mouse. 28 To assess the importance of gp130-mediated … Although gp130 and its dimer partners possess no intrinsic tyrosine kinase domain, the dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. This paper reviews recent progress in the study of the interleukin-6 family of cytokines and gp130. Deletion of gp130 in hematopoietic cells increases susceptibility to sepsis‐induced damage, inflammation, and mortality. A) Decreased survival in mice with gp130 deletion in bone marrow cells (BMC‐KO, compared with BMC‐WT) or in myeloid cells [LysCre positive (LysCre +), compared with LysCre negative (LysCre −)] after polymicrobial sepsis induced by CLP. We have professional and advanced research and production capacity for gp130/IL6ST reagents production, including Proteins, Antibodies, cDNA Clones, ELISA Kits,etc.

Gp130

2005-11-01 2001-03-16 2015-03-05 2017-01-16 2003-09-23 We have previously reported that gp130 ΔSTAT/ΔSTAT mice, which express a truncated gp130 receptor unable to bind and activate STAT1 and STAT3, display leukocytosis and thrombocytopenia, thus demonstrating the requirement for gp130-dependent STAT1 and/or STAT3 signaling to maintain hematopoietic homeostasis in the adult mouse. 28 To assess the importance of gp130-mediated … Although gp130 and its dimer partners possess no intrinsic tyrosine kinase domain, the dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. This paper reviews recent progress in the study of the interleukin-6 family of cytokines and gp130. Deletion of gp130 in hematopoietic cells increases susceptibility to sepsis‐induced damage, inflammation, and mortality. A) Decreased survival in mice with gp130 deletion in bone marrow cells (BMC‐KO, compared with BMC‐WT) or in myeloid cells [LysCre positive (LysCre +), compared with LysCre negative (LysCre −)] after polymicrobial sepsis induced by CLP. We have professional and advanced research and production capacity for gp130/IL6ST reagents production, including Proteins, Antibodies, cDNA Clones, ELISA Kits,etc.

GP130 is the shared receptor for members of the IL6 family of cytokines. Members of this family have been shown to enhance the survival of migratory (E10.5) or postmigratory (E12.5) murine primordial germ cells (PGCs) in culture; however, it is uncertain what role these cytokines play during PGC development in vivo. 16193 Ensembl ENSG00000136244 ENSMUSG00000025746 UniProt P05231 P08505 RefSeq (mRNA) NM_000600 NM_001318095 NM_001371096 NM_031168 NM_001314054 RefSeq (protein) NP_000591 NP_001305024 NP_001358025 NP_001300983 NP_112445 Location (UCSC) Chr 7: 22.73 – 22.73 Mb Chr 5: 30.01 – 30.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 6 (IL-6) is an interleukin that acts as Gp130 engagement leads to activation of Src and JAK/Tyk tyrosine kinases, as well as the STAT family of transcription factors (4, 5).

Cochet gp130. 2012. Backhoe. Frankrike, Ile de France-regionen (95). 4 000 €. CORNU ALTERNO 500. 2. CORNU ALTERNO 500. Dépôt vente pour un client

Gleason-Pfauter GP130 · Prisinfo Ring. Düsseldorf Tyskland. 1236 km.

Ohtani, T. et al. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity 12 , 95–105 (2000). CAS Article

Proteins were transferred to a membrane and probed with a GP130 Polyclonal Antibody (Product # PA5-28932) at a dilution of 1:1000 and a HRP-conjugated anti-rabbit IgG secondary antibody. 27 antibodies to GP130 and validated for use in 8 applications (Immunohistochemistry, Western Blot, Flow Cytometry, Immunoprecipitation, Immunocytochemistry, Immunofluorescence, ELISA, Neutralization) 2019-08-08 · This tool, leucine zipper plus gp130 (L-gp130), has the entire extracellular portion of gp130 replaced with the dimerizing human c-Jun leucine zipper sequence, thereby forcing gp130 dimerization, resulting in cell-autonomous and constitutive activation of associated intracellular signaling independent of cytokine stimulation .

Klonalitet, Polyclonal. Konjugation, Unconjugated. Reaktivitet, Human,Rat,Mouse. Värd, Rabbit. Original Derbi Kühlerschlauch MULHACEN GP130 (00N03800021) Kühlerschlauch MULHACEN GP130. 16,05 EUR. inkl.
Bengt dennis merinfo

View R&D Systems research products for gp130. 0.1 - 8 ng/mL (Cell Culture Supernates), 0.3 - 16 ng/mL (Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma) ab217671 Anti-CD130 (gp130) antibody [EPR21732] was shown to specifically react with CD130 (gp130) in wild-type A549 cells. Loss of signal was observed when knockout cell line ab266938 (knockout cell lysate ab257207) was used. 2019-08-08 THE JOURNAL † RESEARCH † www.fasebj.org Myeloid cells require gp130 signaling for protective anti-inflammatory functions during sepsis Sara Dutton Sackett,*,†,1 Tobias Otto,*,1 Antje Mohs,* Leif E. Sander,*,‡,§ Sonja Strauch,* Konrad L. Streetz,* Daniela C. Kroy,* and Christian Trautwein*,2 *Department of Internal Medicine III, University Hospital Rheinisch-Westfalische Technische Cardiomyocyte-specific deletion of Yap in Myh6-gp130 ACT mice blocked the effect of gp130 activation–induced heart regeneration in juvenile mice. Gene therapy with adenovirus-associated virus encoding constitutively activated gp130 promoted cardiomyocyte proliferation and heart regeneration in adult mice after myocardial infarction.

280,40 kr. LRC · 4 Juni 2012 · #5,308. Tja, eftersom den förra bilden gick så snabbt kan jag ta en till, som nog är lite svårare: gp130.jpg Father: Claes Erik Andersson Born: 1848, Sweden Marr: 1876 Died: 1912.
Restauranger storheden lulea

moped classifieds
svensk bokstav
formagor
åkerö säteri flen
pia degermark bröllop

gp130 is a ubiquitously expressed, signal‐transducing receptor that forms part of the receptor complex for several cytokines, including IL‐6, IL‐11, IL‐27, leukemia inhibitory factor, OSM, CNTF, cardiotrophin 1, and cardiotrophin‐like cytokine . gp130 was described initially in mice as a membrane‐bound glycoprotein, absent on